Abstract Background Critically ill patients with sepsis and acute respiratory distress syndrome have severely altered physiology and immune system modifications. RNA splicing is a basic molecular mechanism influenced by physiologic alterations. Immune checkpoint inhibitors. such as B and T Lymphocyte Attenuator (BTLA) have previously been shown to influence outcomes in critical illness. https://www.jmannino.com/super-super-University-of-Arizona-Primary-Mark-iPhone-14-Plus-MagSafe-Case-p76978-deal-zone/